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  • Title: [Clinical effect of rock salt aerosol therapy in treatment of occupational allergic contact dermatitis].
    Author: Sun ML, Song L, Yang HM, Shi DM, Bi YL.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2017 Feb 20; 35(2):141-143. PubMed ID: 28355706.
    Abstract:
    Objective: To investigate the clinical effect and safety of rock salt aerosol therapy in the treatment of occupational allergic contact dermatitis. Methods: A total of 65 patients with acute exacerbation of occupational allergic contact dermatitis who were treated in the Outpatient Service and Inpatient Department of our hospital from March 2013 to December 2015 were enrolled and randomly divided into observation group and control group using a random number table. Both groups were givensymptomatic treatment including desensitization, and the patients in the observation group were given rock salt aerosol therapy for 2 courses in addition to the symptomatic treatment. The changes in symptoms, signs, blood eosinophil count, and IgE were observed. Results: There were significant changes in symptom score at the first and second courses of the treatment (P<0.05) , and there was an interaction between time of therapy and grouping (P<0.05) . There was no significant difference in symptom score before treatment between the two groups (P>0.05) , while there were differences at the first and second courses of the treatment (P<0.05) . After the second course of treatment, the observation group had a significantly higher overall response rate than the control group (P<0.05) ; both groups had significant reductions in blood eosinophil count and the observation group had a significantly greater reduction than the control group (P<0.05) . After two courses of treatment, both groups had significant increases in the number of patients with normal IgE (both P<0.05) , and after the second course of treatment, the observation group had a significantly higher number than the control group (P<0.05) . Both groups had mild adverse events, which did not affect the treatment. Conclusion: In the treatment of occupational allergic contact dermatitis, rock salt aerosol therapy has a certain effect on the recovery of symptoms, signs, blood eosinophil count, and IgE. 目的： 评价岩盐气溶胶疗法治疗职业性变应性接触性皮炎的临床疗效和安全性。 方法： 选择2013年3月至2015年12月在我院门诊和住院部的65例急性发作期职业性变应性接触性皮炎患者，按随机数字表法将其分为观察组和对照组。两组均给予脱敏等对症治疗，观察组在此治疗基础上加用岩盐气溶胶疗法，治疗2个疗程，观察两组患者症状、体征、血嗜酸性粒细胞数及IgE的变化情况。 结果： 患者治疗前及治疗的第1、2疗程症状体征积分差异均有统计学意义（均P<0.05），治疗时间和分组有交互作用（P<0.05），观察组和对照组患者治疗前症状体征积分评分差异无统计学意义（P>0.05），第1、2疗程差异均有统计学意义（均P<0.05）。观察组治疗第2个疗程后总有效率明显高于对照组，差异有统计学意义（P<0.05）；治疗第2个疗程后，观察组和对照组患者血嗜酸性粒细胞数较治疗前明显降低（t=5.951、3.219，均P<0.05），且与对照组比较，观察组患者血嗜酸性粒细胞数明显降低，差异有统计学意义（t=2.072，P<0.05）；治疗两个疗程后，观察组和对照组患者IgE正常例数均较治疗前增多（χ(2)=47.60、19.79，均P<0.05），且治疗第2个疗程后观察组IgE正常例数明显高于对照组（χ(2)=8.36，P<0.05）。两组患者不良反应较轻，均未影响疗程。 结论： 岩盐气溶胶疗法对职业性变应性接触性皮炎患者症状、体征、血嗜酸性粒细胞数及IgE的恢复有一定疗效。.
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