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  • Title: Effects of neostigmine, edrophonium, 4-aminopyridine and their combinations.
    Author: Treffers R, Frankhuyzen AL, Booij LH.
    Journal: Acta Anaesthesiol Belg; 1988; 39(1):55-8. PubMed ID: 2835880.
    Abstract:
    A study was carried out in the in-vitro rat phrenic nerve hemidiaphragm preparation to find a fast and strong working antagonist of non-depolarizing muscle relaxants. We studied neostigmine, edrophonium, 4-aminopyridine and their combinations from the cumulative concentration response curves of pancuronium. Neostigmine, edrophonium and 4-aminopyridine all antagonized the effect of pancuronium. Neostigmine and 4-aminopyridine did potentiate each other as did neostigmine and edrophonium. The combination of edrophonium and 4-aminopyridine showed less total effect than the addition of their individual effect. We conclude that the mechanisms of action of neostigmine and edrophonium are different.
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