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  • Title: Red blood cells galactose-1-P-urydil transferase in senile and presenile cataracts.
    Author: Auricchio G, Rinaldi E, Simonelli F, De Rosa G.
    Journal: Metab Pediatr Syst Ophthalmol (1985); 1985; 8(4):160-1. PubMed ID: 2836694.
    Abstract:
    There are conflicting reports in the literature regarding the role of partial deficiency of "galactosemic" enzymes (galactose-1-P-urydil transferase and galactokinase) in the development of infantile and presenile cataract. The AA. have investigated the levels of Red Blood Cell Galactose-1-P-urydil transferase in 39 cataractous patients and in 22 age matched controls. A weak correlation between the enzymatic activity deficiency and the presenile cataract has been identified. The results suggest that a chronic impairment of galactose metabolism may be a contributory risk factor in the pathogenesis of presenile cataracts; however, further investigations are required to assess the actual significance of the findings of the present paper.
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