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  • Title: A 3H-flunitrazepam binding inhibitor is present in psychiatric patients' sera.
    Author: Marazziti D, Pietrini P, Martini C, Giannaccini G, Perugi G, Placidi GF, Cassano GB, Lucacchini A.
    Journal: Neuropsychobiology; 1987; 18(2):74-6. PubMed ID: 2836759.
    Abstract:
    We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-flunitrazepam binding specifically in the samples taken from the patients' groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.
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