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  • Title: The antiviral effect of human interferon alpha is dependent on phosphoinositide-derived messengers.
    Author: Cernescu C, Constantinescu SN, Baltă F, Popescu LM.
    Journal: Virologie; 1988; 39(1):3-6. PubMed ID: 2837002.
    Abstract:
    Neomycin the putative blocker of membrane polyphosphoinositide hydrolysis, inhibited the antiviral activity of human interferon alpha, when tested on human quiescent fibroblasts challenged with vesicular stomatitis virus. The anti-interferon effect of neomycin could be correlated in terms of dose dependence for both neomycin (0.05-1 mM) and interferon (100-5,000 IU/ml). The results suggest that the antiviral activity of interferon alpha depends on diacylglycerol formation. Indeed, the synthetic diacylglycerol (50 microM) was as effective as 100 IU/ml interferon in inducing the antiviral state.
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