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  • Title: Human B and T lymphocytes convert leukotriene A4 into leukotriene B4.
    Author: Odlander B, Jakobsson PJ, Rosén A, Claesson HE.
    Journal: Biochem Biophys Res Commun; 1988 May 31; 153(1):203-8. PubMed ID: 2837199.
    Abstract:
    Incubation of human tonsillar B lymphocytes and peripheral blood T lymphocytes with leukotriene A4 led to the formation of leukotriene B4. The purity of these cell suspensions was more than 99%, containing less than 0.5% monocytes. Incubation of purified B or T lymphocytes with the calcium ionophore A23187 did not lead to the formation of any detectable amounts of leukotrienes. Several established cell lines of B and T lymphocytic origin were also found to convert leukotriene A4 into leukotriene B4, showing that monoclonal lymphocytic cells possess leukotriene A4 hydrolase activity.
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