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  • Title: Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use.
    Author: Haaland RE, Holder A, Evans-Strickfaden T, Nyagol B, Makanga M, Oyaro B, Humwa F, Williams T, McLellan-Lemal E, Desai M, Huey MJ.
    Journal: Contraception; 2017 Jun; 95(6):602-604. PubMed ID: 28372978.
    Abstract:
    OBJECTIVE: This study sought to measure residual contraceptive hormone levels in vaginal rings as an adherence marker for monitoring product use in clinical trials. STUDY DESIGN: Residual etonogestrel and ethinyl estradiol levels from used NuvaRings® of 26 self-reported adherent women enrolled in a clinical trial of vaginal ring acceptability were compared to those from 16 women who used NuvaRing® as their contraceptive choice. RESULTS: Twenty-one (81%) clinical trial rings had contraceptive hormone levels within the range of those used as a contraceptive choice. Five returned rings had unused or discordant levels of residual contraceptive hormones. CONCLUSION: Residual vaginal ring drug levels could help assess adherence in clinical trials.
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