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  • Title: Tac expression induced by Epstein-Barr virus is restricted on non-transformable B lymphocytes.
    Author: Gosselin J, Desrosiers M, Mercier G, Menezes J, Lamoureux G, Oth D.
    Journal: Immunol Lett; 1988 May; 18(1):9-13. PubMed ID: 2837437.
    Abstract:
    During the course of a comparative study dealing with the immortalization of lymphocytes from a large number of normal healthy donors, we found that B cells of two of these individuals could not be immortalized by Epstein-Barr virus (EBV) under the standard conditions. The expression of the Tac antigen on the membrane of EBV-infected B cells from these two donors was compared with that of B cells from EBV immortalization-susceptible ones. The method used was two-colour immunofluorescence cytofluorometer analysis. We found that the Tac antigen expression was significantly and repeatedly reduced in the case of the two immortalization-resistant donors. This difference might be related to a genetic control of the resistance to EBV-immortalization.
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