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  • Title: Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double-Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery.
    Author: Andrea KA, Wang L, Carrier AJ, Campbell M, Buhariwalla M, Mutch M, MacQuarrie SL, Bennett C, Mkandawire M, Oakes K, Lu M, Zhang X.
    Journal: Langmuir; 2017 Apr 25; 33(16):3926-3933. PubMed ID: 28375634.
    Abstract:
    Magnesium aluminum-layered double-hydroxide nanoparticles (LDH NPs) are promising drug-delivery vehicles for gene therapy, particularly for siRNA interference; however, the interactions between oligo-DNA and LDH surfaces have not been adequately elucidated. Through a mechanistic study, oligo-DNA initially appears to rapidly bind strongly to the LDH outer surfaces through interactions with their phosphate backbones via ligand exchange with OH- on Mg2+ centers and electrostatic forces with Al3+. These initial interactions might precede diffusion into interlayer spaces, and this knowledge can be used to design better gene therapy delivery systems.
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