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  • Title: [Expression and significance of STAT6 in solitary fibrous tumor].
    Author: Ding ZY, Wang YF, Wang X, Rao Q.
    Journal: Zhonghua Bing Li Xue Za Zhi; 2017 Apr 08; 46(4):235-239. PubMed ID: 28376588.
    Abstract:
    Objective: To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT). Methods: Eighty cases of SFT were evaluated. The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method. The results were analyzed and relevant literature were reviewed. Results: The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3.3% (3/90). The difference was significant (P<0.05). The expression rates of CD34, CD99 and bcl-2 were 88.8% (71/80), 76.3% (61/80) and 75.0% (60/80) in SFT, respectively, which were significantly different from STAT6 expression rate (P<0.05). Conclusions: The expression of STAT6 in SFT has high sensitivity (97.5%) and specificity (96.7%). The expression of STAT6 in SFT is higher than that of CD34, CD99 and bcl-2. STAT6 may be a useful marker for clinical diagnosis of SFT. 目的：探讨孤立性纤维性肿瘤(solitary fibrous tumour，SFT)的临床病理特征及免疫组织化学标志物信号转导及转录激活因子6(signal transducers and activators of transcription 6，STAT6)的临床病理诊断意义及鉴别诊断价值。 方法：对80例SFT进行回顾性研究，并复习相关文献资料，采用免疫组织化学EnVision法检测STAT6、CD34、CD99和bcl－2蛋白在SFT和其他各型软组织肿瘤中的表达情况，并分析其临床病理意义。 结果：STAT6在SFT和对照组软组织肿瘤中的阳性率分别为97.5%(78/80)和3.3%(3/90)，两者之间的表达差异具有统计学意义(P<0.05)；在SFT中CD34、CD99和bcl－2的阳性率分别为88.8%(71/80)、76.3%(61/80)和75.0%(60/80)，三者与STAT6的表达差异均具有统计学意义(P<0.05)。STAT6在SFT中表达的灵敏度为97.5%(78/80)，特异度为96.7%(87/90)。 结论：STAT6在SFT细胞核中的表达具有较高的灵敏度和特异度，远高于CD34、CD99和bcl－2这3种常用临床标志物，可作为临床诊断SFT的又一个有用标志物，具有重要的临床诊断和鉴别诊断意义。.
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