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  • Title: Abnormal scintigraphic evolution in AA hepatic amyloidosis.
    Author: Lomeña F, Roselló R, Pons F, Grau M, García A, Catafau A, Setoain J.
    Journal: Clin Nucl Med; 1988 Mar; 13(3):194-6. PubMed ID: 2838214.
    Abstract:
    A patient with AA amyloidosis secondary to ankylosing spondylitis showed intense liver uptake of Tc-99m MDP on bone imaging. The biopsy showed hepatic amyloid deposition. A repeat bone scan with Tc-99m MDP 1 year later was negative, although the clinical signs and liver function tests of the patient had not changed. A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis.
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