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  • Title: [Establishment of a human lung alveolar cancer cell strain and its characteristics].
    Author: Liang MD, Hu MY, Jia W, Wang ZX, Mong FH, Zhou KM.
    Journal: Zhonghua Zhong Liu Za Zhi; 1987 Sep; 9(5):336-8, 18. PubMed ID: 2838234.
    Abstract:
    A human lung alveolar cancer cell strain (HAC-84), isolated from lung adenocarcinoma cell line in Gejiu (GLC-82) by colony selecting method, has been continuously propagated in vitro for more than 2 years through 164 passages till May 1 st 1986. HAC has the typical malignant characteristics as GLC. There are plenty of phospholipid and osmiophilic multilamellar bodies in the cytoplasm of all cells and the membrane-like material in most of the nuclei, which differentiate HAC from GLC and the other types of lung cancers. The cytoplasmic inclusions are the same as those found in type II alveolar epithelial cells of the lung. So, HAC, originated from the type II alveolar cells, is identified as human lung alveolar cancer cell strain. It is significant in the research of the properties and origin of the alveolar cancer, the action and formation of the alveolar surfactants.
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