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  • Title: Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation.
    Author: Wang M, Van Haastert PJ, Devreotes PN, Schaap P.
    Journal: Dev Biol; 1988 Jul; 128(1):72-7. PubMed ID: 2838350.
    Abstract:
    cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating cells, the antigen is uniformly distributed over the cell surface. Persistent cAMP stimulation, which leads to down-regulation of cAMP binding activity, induces a striking rearrangement of receptor antigen into patches or internal vesicles. A similar patching of receptor antigen is observed during tight aggregate formation, when surface cAMP binding activity decreases. These observations indicate that receptor down-regulation involves receptor agglomeration and suggest that receptor down-regulation takes place in vivo, when tight aggregates are being formed.
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