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  • Title: Oral submucous fibrosis: An update on pathophysiology of malignant transformation.
    Author: Arakeri G, Patil SG, Aljabab AS, Lin KC, Merkx MAW, Gao S, Brennan PA.
    Journal: J Oral Pathol Med; 2017 Jul; 46(6):413-417. PubMed ID: 28391621.
    Abstract:
    Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.
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