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  • Title: Effects of 5-methoxy-N,N-dimethyltryptamine on behavior and raphe unit activity in freely moving cats.
    Author: Trulson ME, Jacobs BL.
    Journal: Eur J Pharmacol; 1979 Feb 15; 54(1-2):43-50. PubMed ID: 283930.
    Abstract:
    5-methoxy-N,N-dimethyltryptamine (5-MeODMT) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from a 15% decrease at 10 microgran/kg, i.m., to a virtual complete depression of activity at 250 microgram/kg. 5-MeODMT's effects on raphe units occurred with a very short latency (3-5 min) and its duration of action was dose-dependent and limited to an hour or less. The degree of depression of raphe unit activity was directly related to the frequency of occurrence of a number of hallucinogen-specific cat behaviors such as limb flick and abortive groom. There was also a close temporal correlation between the depression of raphe unit activity and the occurrence of these behaviors. These data indicate that the effects of 5-MeODMT may be primarily dependent on its actions upon brain serotonin neurons.
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