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  • Title: Redox transformations of quinone antitumor drugs in liver microsomes.
    Author: Rumyantseva GV, Weiner LM.
    Journal: FEBS Lett; 1988 Jul 18; 234(2):459-63. PubMed ID: 2839377.
    Abstract:
    The hydroxyl radical has been spin trapped in microsomal and purified NADPH-cytochrome P-450 reductase systems in the presence of adriamycin, daunomycin and mitomycin C. The presence of a lag period in quinone-stimulated spin-adduct formation is associated with oxygen removal upon its reduction to H2O2. The hydroxy radical generation has been stimulated by the Fe-EDTA complex and completely inhibited by catalase. The mechanism of redox transformations of anthracyclines in a microsomal system has been proposed The single electron reduced quinone-containing anticancer antibiotics play the following roles: (i) they reduce oxygen to H2O2 and (ii) they reduce the ferric ions necessary for H2O2 decomposition with hydroxyl radical formation.
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