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  • Title: Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens.
    Author: Ramqvist T, Pallas DO, DeAnda J, Ahrlund-Richter L, Reinholdsson G, Roberts TM, Schaffhausen BS, Dalianis T.
    Journal: Int J Cancer; 1988 Jul 15; 42(1):123-8. PubMed ID: 2839427.
    Abstract:
    The relationship between the polyoma virus tumor-specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli. The 2 proteins induced protective immunity against polyomavirus-induced tumors, but not against non-polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.
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