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  • Title: RGD-mediated delivery of small-molecule drugs.
    Author: Katsamakas S, Chatzisideri T, Thysiadis S, Sarli V.
    Journal: Future Med Chem; 2017 Apr; 9(6):579-604. PubMed ID: 28394627.
    Abstract:
    Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to ανβ3, α5β1 and ανβ6 integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.
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