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  • Title: A new p-hydroxybenzoic acid derivative from an endophytic fungus Penicillium sp. of Nerium indicum.
    Author: Ma YM, Qiao K, Kong Y, Guo LX, Li MY, Fan C.
    Journal: J Asian Nat Prod Res; 2017 Dec; 19(12):1245-1251. PubMed ID: 28395521.
    Abstract:
    A new p-hydroxybenzoic acid derivative named 4-(2'R, 4'-dihydroxybutoxy) benzoic acid (1) was isolated from the fermentation of Penicillium sp. R22 in Nerium indicum. The structure was elucidated by means of spectroscopic (HR-ESI-MS, NMR, IR, UV) and X-ray crystallographic methods. The antibacterial and antifungal activity of compound 1 was tested, and the results showed that compound 1 revealed potent antifungal activity against Colletotrichum gloeosporioides, Alternaria alternata, and Alteranria brassicae with MIC value of 31.2 μg/ml.
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