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  • Title: [Aldosterone content of the blood and tissues in rats with an altered level of adrenergic activity].
    Author: Korovin KF, Kovalev OA, Iampol'skaia LI, Samokhin GS.
    Journal: Probl Endokrinol (Mosk); 1988; 34(2):62-4. PubMed ID: 2839821.
    Abstract:
    The content of aldosterone (A) was studied in rat adrenal glands, blood plasma and peripheral tissues--in the myocardium, skeletal muscles, thymus and liver--1 h after the administration of alpha-adrenergic stimulator noradrenaline and beta-adrenergic stimulator isoprenaline and after simultaneous administration of alpha- and beta-blockers and a sympatholytic agent (pyrroxan, propranolol and bretylium tosylate respectively). Adrenergic stimulation did not change the level of A in the adrenal glands, raised its blood concentration and, to a greater extent, its level in the peripheral tissues. A marked increase in the blood concentration of A resulted from isoprenaline and its accumulation in tissues--from noradrenaline. A decrease in the level of adrenergic activity considerably lowered the A content in the adrenal glands, blood plasma and peripheral tissues excluding the myocardium where this value was higher than in the blood.
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