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  • Title: Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings.
    Author: Hollander E, Fay M, Cohen B, Campeas R, Gorman JM, Liebowitz MR.
    Journal: Am J Psychiatry; 1988 Aug; 145(8):1015-7. PubMed ID: 2839998.
    Abstract:
    Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.
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