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  • Title: Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report.
    Author: Mostafazadeh B, Farzaneh E, Paeezi M, Nikkhah F.
    Journal: Med Leg J; 2017 Dec; 85(4):221-223. PubMed ID: 28403672.
    Abstract:
    The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime. If the poisoning is severe, a high dose of this combination of medicines may be needed, but this may cause serious side effects: paralytic ileus or even megacolon; however, these gastrointestinal events are very rare. Here, we report a case of organophosphate poisoning where atropine therapy was given and led to drug-associated toxic megacolon.
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