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  • Title: Intraepithelial and invasive neoplasia of the vulva in association with human papillomavirus infection.
    Author: Planner RS, Hobbs JB.
    Journal: J Reprod Med; 1988 Jun; 33(6):503-9. PubMed ID: 2841459.
    Abstract:
    Colposcopic examination of 335 women with cytologically detected human papillomavirus (HPV) revealed involvement of the cervix in 316 patients (94%), vagina in 276 (82%) and vulva in 148 (44%). A symptom complex of pruritus and superficial dyspareunia was found in 98 of the 148 patients with vulvar infection (66%). Histologic examination revealed HPV-associated vulvar intraepithelial neoplasia (VIN) in 11 of 148 biopsies (7.4%). Follow-up of the patients with HPV infection with or without VIN showed a spontaneous regression rate of 56% but also demonstrated progression to VIN 3 in two patients and to invasive carcinoma of the vulva in one.
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