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  • Title: Synergistic enhancement of the biliary excretion of cadmium by the simultaneous administration of two dithiocarbamates.
    Author: Bláha K, Cikrt M, Kasparová L, Jones MM.
    Journal: Toxicol Lett; 1988 Aug; 42(2):207-13. PubMed ID: 2841778.
    Abstract:
    The simultaneous i.p. administration of the two chelating agents bis(2-hydroxyethyl)dithiocarbamate (DEDTC) and 4-carboxamidopiperidinedithiocarbamate (INADTC) to rats given cadmium in their drinking water at a level of 50 mg cadmium/liter for 39 days led to a large synergistic effect on the biliary excretion of cadmium. A much smaller synergistic effect on the urinary excretion of cadmium was also noted. When treated with a similar mixture of chelating agents after a similar cadmium-drinking water exposure of 180 days, rats showed significant decreases in both renal and brain cadmium levels.
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