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  • Title: Purification and characterization of human urine-derived digitalis-like factor.
    Author: Goto A, Yamada K, Ishii M, Yoshioka M, Ishiguro T, Eguchi C, Sugimoto T.
    Journal: Biochem Biophys Res Commun; 1988 Aug 15; 154(3):847-53. PubMed ID: 2841934.
    Abstract:
    We were able to purify a digitalis-like factor to apparent homogeneity from human urine based on the inhibitory effect on [3H]-ouabain binding to intact human erythrocytes. This ouabain displacing compound closely resembles ouabain in its polarity, molecular weight, non-peptidic nature and mode of action except for its UV absorbance spectrum. This compound sharing many biological activities of ouabain may be the endogenous ligand for the Na+, K+-ATPase and serve as a specific regulator of the sodium pump.
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