These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Biochemical effects of ryodipine (foridon)--a new calcium antagonist and derivative of 1,4-dihydopyridine].
    Author: Simkhovich BZ, Mezhapuke RIa, Dubur GIa.
    Journal: Farmakol Toksikol; 1988; 51(3):30-4. PubMed ID: 2842181.
    Abstract:
    Ryodipine (foridon)--2, 6-dimethyl-3,5-dicarbomethoxy-4-(o-difluoromethoxyphenyl)-1, 4-dihydropyridine--similarly to nifedipine but at a lesser degree than nicardipine causes an increase of cAMP concentration in the slices of the rabbit myocardium and aorta. This property of 1,4-dihydropyridines is reflected in their effect on the uptake of 45Ca2+ by the myocardial strips. In the range of concentrations of 10(-4)-10(-6)M inhibition of 45Ca2+ transport is enhanced with a decrease of concentrations of the drugs. Under inactivation of potential-dependent transport of Ca2+, 1,4-dihydropyridines enhance the uptake of 45Ca2+. The similar effect was found at incubation of the myocardial slices in a polarizing buffer (2.68 mM K+). Verapamil, irrespective of the degree of depolarization (60,123 mM K+), suppressed in a linear dependence the uptake of 45Ca2+ and failed to influence this process in the absence of potential-dependent transport of Ca2+. By its biochemical effects ryodipine does not differ from the known derivatives of 1,4-dihydropyridine but has, like nifedipine and nicardipine, significant differences as compared with verapamil.
    [Abstract] [Full Text] [Related] [New Search]