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  • Title: Effect of atrial natriuretic factor on corticosteroid production by perifused frog interrenal slices.
    Author: Lihrmann I, Netchitaïlo P, Feuilloley M, Cantin M, Delarue C, Leboulenger F, De Léan A, Vaudry H.
    Journal: Gen Comp Endocrinol; 1988 Jul; 71(1):55-62. PubMed ID: 2842221.
    Abstract:
    In order to investigate a possible role of atrial natriuretic factor (ANF) in the control of corticosteroid biosynthesis in amphibians, we have examined the effect of synthetic ANF (Arg 101-Tyr 126) on perifused frog interrenal slices. ANF did not affect the spontaneous secretion of corticosterone and aldosterone. In contrast, ANF (10(-6) M) inhibited ACTH-and angiotensin II-stimulated corticosteroid production. ANF was more potent in suppressing aldosterone than corticosterone secretion. Immunocytochemical studies using a specific ANF antiserum revealed the presence of ANF-like immunoreactive fibers in the vicinity of interrenal cells. It is thus proposed that, in amphibians, both "hormonal" ANF secreted by myocytes and "neurohormonal" ANF delivered by peptidergic nerve terminals coursing among interrenal cells may partake in the regulation of corticosteroidogenesis.
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