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  • Title: Prevalence of genital HPV infections in a regularly screened population in The Netherlands in relation to cervical cytology.
    Author: Melchers WJ, Herbrink P, Quint WG, Walboomers JM, Meijer CJ, Lindeman J.
    Journal: J Med Virol; 1988 May; 25(1):11-6. PubMed ID: 2842442.
    Abstract:
    To determine the prevalence of human papilloma virus (HPV) genotypes in relation to cervical cytology, 1,290 cervical samples from a regularly screened population of 30-55-year-old women were investigated. Gynaecological specimens, obtained from the cervix, were cytologically classified and screened for the presence of HPVs 6/11 and 16/18 using dot-spot DNA hybridisation. Of the cervical samples containing unequivocally normal cells, 21 of 1,271 (1.6%) were found positive for HPV, and of the cervical samples containing cells with mild dysplasia, 6 of 14 (43%) were found positive for HPV. All five samples containing cells consistent with severe dysplasia or carcinoma in situ were found positive for HPV. Approximately 50% of the HPV-positive samples contained HPV 16 and/or HPV 18 DNA.
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