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  • Title: Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m.
    Author: Sazonova SI, Il'yushenkova YN, Lishmanov YB, Tsibul'nikov SV, Skuridin VS, Nesterov EA, Varlamova NV, Il'ina EA, Filimonov VD, Belyanin MV, Stepanova EV, Minin SM.
    Journal: Bull Exp Biol Med; 2017 Apr; 162(6):746-749. PubMed ID: 28429212.
    Abstract:
    Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123I-PMPDA. 99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.
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