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  • Title: Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam.
    Author: Moosdeen F, Williams JD, Yamabe S.
    Journal: Antimicrob Agents Chemother; 1988 Jun; 32(6):925-7. PubMed ID: 2843088.
    Abstract:
    The antibacterial activity, binding to penicillin-binding proteins, and morphological changes effected by YTR 830, a sulfone beta-lactamase inhibitor, were studied in comparison with those of other beta-lactamase inhibitors. YTR 830 had very poor antibacterial activity, bound to PBP 2 of gram-negative organisms, and at the MIC caused rapid lysis of spheroplasts formed.
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