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  • Title: [Repeated arterial infusion therapy with ADM and CDDP in liver cancer using implanted reservoir].
    Author: Nagabuchi E, Une Y, Sato Y, Ito Y, Ogasawara K, Koike M, Isizu H, Shimamura T, Uchino J.
    Journal: Gan To Kagaku Ryoho; 1988 Aug; 15(8 Pt 2):2419-23. PubMed ID: 2843108.
    Abstract:
    Between January 1986 and March 1988, 35 cases with primary liver cancer were treated by arterial infusion therapy using implanted reservoir. Twenty-one of these cases were treated by the repeated infusion of ADM and CDDP. Results were as follows. 1) Three of 7 non-curatively resected cases died, with a mean survival time of 11 months. Four cases survival for at most 14 months. 2) The response rate (PR) of whole unresectable cases was 29.2%. The cumulative survival rate after treatment was 52.5% at one year. 3) The response rate (PR) of the unresectable cases which were treated with ADM CDDP intraarterial infusion was 33.3%. The cumulative survival rate after treatment was 63.5% at one year. 4) Severe side effects and complications were not seen. We suggested that this form of therapy could prolong the survival time of unresectable hepatoma.
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