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  • Title: Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes.
    Author: Ng DS, Wong K.
    Journal: Biochem Biophys Res Commun; 1988 Aug 30; 155(1):311-6. PubMed ID: 2843182.
    Abstract:
    Binding of platelet-activating factor (PAF) to human peripheral blood mononuclear leukocytes was time-dependent, reversible, and saturable. [3H]PAF binding to the cells was inhibited dose-dependently by unlabeled PAF and PAF receptor antagonists: L-659,989, triazolam, and alprazolam. Scatchard analysis of saturation binding data indicated one class of receptors for PAF with KD = 5.7 nM and Bmax = 18 fmol/10(6) cells (11,100 receptors/cell). PAF (10 nM) increased intracellular free calcium concentration in human lymphocytes and this effect was inhibited by L-659,989 dose-dependently. Our data suggest that human peripheral blood mononuclear leukocytes have specific receptors for PAF.
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