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  • Title: Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex.
    Author: Hrabina O, Kasparkova J, Suchankova T, Novohradsky V, Guo Z, Brabec V.
    Journal: Metallomics; 2017 May 24; 9(5):494-500. PubMed ID: 28436510.
    Abstract:
    The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4'-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3'-3' direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.
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