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  • Title: [Effect of neutral muscle proteases on parameters of the contraction of isolated myocardial strips from albino rats during overload and during the period of readaptation].
    Author: Barinian SB, Oganesian SS, Eloian MA.
    Journal: Kosm Biol Aviakosm Med; 1988; 22(3):58-60. PubMed ID: 2843713.
    Abstract:
    The treatment of an isolated myocardial strip with Ca2+-activated neutral muscle proteases reduced the contraction amplitude and the relaxation rate of the myocardium by 21.0 +/- 1.7% and 25.0 +/- 1.6%, respectively, and the tension development rate--by 13.0 +/- 1.0%. In the animals exposed to +5 Gz (for 25 min daily during 15 days) the inhibitory effect of neutral proteases on the contractile function of an isolated myocardial strip increased from 23.0 +/- 1.7% to 34.0 +/- 4.3%. The initial sensitivity of the contraction apparatus to proteases did not return to the baseline after 30 days of readaptation.
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