These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Toxicity and bioaccumulation of three hexabromocyclododecane diastereoisomers in the marine copepod Tigriopus japonicas.
    Author: Hong H, Lv D, Liu W, Huang L, Chen L, Shen R, Shi D.
    Journal: Aquat Toxicol; 2017 Jul; 188():1-9. PubMed ID: 28437657.
    Abstract:
    The three major hexabromocyclododecane (HBCD) diastereoisomers, i.e. α-, β- and γ-HBCD, have distinct physical and chemical properties that may potentially result in different levels of bioaccumulation and toxicity in aquatic organisms. To assess the impact of diastereomeric variation in HBCDs, the marine copepod Tigriopus japonicus was exposed to α-, β- and γ-HBCD in isolation. Results showed that all the three diastereoisomers had a similar potency to cause growth delay in T. japonicas. Variation was observed in the overall survival rate with exposure to α- and β-HBCD, and this resulted in significantly higher lethal toxicity in T. japonicas than that with exposure to γ-HBCD. Exposure to α-, β- and γ-HBCD led to the generation of ROS in T. japonicas, a possibly toxic mechanism. Both α- and β-HBCD showed a higher potential to induce oxidative stress, which may be a factor in the higher lethal toxicity observed with α- and β-HBCD exposure. It is of note that T. japonicus was found to be more sensitive to all three diastereoisomers in the F1 generation than in the F0 generation. The bioconcentration potential of HBCD diastereoisomers can be ranked in the order α-HBCD>γ-HBCD>β-HBCD and was found to be higher in T. japonicus than has been reported for fish species.
    [Abstract] [Full Text] [Related] [New Search]