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  • Title: Direct use of allylic alcohols and allylic amines in palladium-catalyzed allylic amination.
    Author: Jing J, Huo X, Shen J, Fu J, Meng Q, Zhang W.
    Journal: Chem Commun (Camb); 2017 May 04; 53(37):5151-5154. PubMed ID: 28439586.
    Abstract:
    Allylic alcohols and allylic amines were directly utilized in a Pd-catalyzed hydrogen-bond-activated allylic amination under mild reaction conditions in the absence of any additives. The cooperative action of a Pd-catalyst and a hydrogen-bonding solvent is most likely responsible for its high reactivity. The catalytic system is compatible with a variety of functional groups and can be used to prepare a wide range of linear allylic amines in good to excellent yields. Furthermore, this methodology can be easily applied to the one-step synthesis of two drugs, cinnarizine and naftifine, on a gram scale.
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