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  • Title: Hepatitis B virus infection assessed 3 to 18 years after vaccination in Cuban children and adolescents born to HBsAg-positive mothers.
    Author: Rodríguez Lay LLA, Bello Corredor M, Montalvo Villalba MC, Chibás Ojeda AG, Sariego Frómeta S, Diaz González M, Abad Lamoth Y, Sánchez Wong M, Sausy A, Muller CP, Hübschen JM.
    Journal: Arch Virol; 2017 Aug; 162(8):2393-2396. PubMed ID: 28439708.
    Abstract:
    Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers ≥10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable. Our data suggest that the vaccine protected 93.8% of children in this high-risk group against chronic HBV infection. Occult infections should be considered even in countries with low endemicity and high vaccination coverage.
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