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  • Title: MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.
    Author: Sheng N, Tan G, You W, Chen H, Gong J, Chen D, Zhang H, Wang Z.
    Journal: Cancer Med; 2017 Jun; 6(6):1331-1340. PubMed ID: 28440035.
    Abstract:
    MicroRNA-145 (miR-145), as a tumor-suppressive miRNA, has been demonstrated down-regulated in colorectal cancer (CRC) cells, and could inhibit CRC cells growth. However, the molecular pathway in which miR-145 modulates CRC malignant transformation has not been fully revealed. Here, we reported an intense correlation between the expressions of PAK4 and miR-145 in human CRC cell lines. Transwell assay verified overexpression of miR-145, as well as knockdown of PAK4, significantly suppressed cell migration and invasion ability. The impaired migration and invasion ability of SW1116 cells was affected through the down-regulation of phosphorylation level of LIMK1 and cofilin in a PAK4-dependent manner. Collectively, we have demonstrated that miR-145 suppressed CRC migration and invasion through PAK4 pathway, which provides an attractive microRNA-based therapeutic target for CRC.
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