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  • Title: Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births.
    Author: Šplíchal Z, Zlámal F, Máchal J, Lipková J, Pavlová T, Hodická Z, Ventruba P, Vašků A, Bienertová-Vašků J.
    Journal: J Matern Fetal Neonatal Med; 2018 Jul; 31(13):1689-1695. PubMed ID: 28440092.
    Abstract:
    OBJECTIVE: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs). MATERIALS AND METHODS: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n = 16) and without (n = 14) preterm premature rupture of membranes (PPROM). RESULTS: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p = .015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p = .990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established. CONCLUSIONS: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
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