These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dimerization of neurokinin A and B COOH-terminal heptapeptide fragments enhanced the selectivity for tachykinin receptor subtypes.
    Author: Kodama H, Shimohigashi Y, Sakaguchi K, Waki M, Takano Y, Yamada A, Hatae Y, Kamiya H.
    Journal: Eur J Pharmacol; 1988 Jul 07; 151(2):317-20. PubMed ID: 2844557.
    Abstract:
    We have synthesized dimeric analogues of neurokinin A and B COOH-terminal heptapeptide fragments and evaluated their biological activities to contract isolated smooth muscle preparations of the guinea-pig ileum and rat vas deferens. The dimers were fairly active and showed two-fold increased selectivity for receptors in the guinea-pig ileum as compared with monomers. Extremely slow dissociation indicated a possible bivalent interaction between dimer and receptor.
    [Abstract] [Full Text] [Related] [New Search]