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  • Title: Nanoemulsion is an effective antimicrobial for methicillin-resistant Staphylococcus aureus in infected wounds.
    Author: Cao Z, Spilker T, Fan Y, Kalikin LM, Ciotti S, LiPuma JJ, Makidon PE, Wilkinson JE, Baker JR, Wang SH.
    Journal: Nanomedicine (Lond); 2017 May; 12(10):1177-1185. PubMed ID: 28447896.
    Abstract:
    AIM: To develop NB-201, a nanoemulsion compound, as a novel microbicidal agent against methicillin-resistant Staphylococcus aureus (MRSA) infection, which is a common threat to public health but with limited therapeutic options. MATERIALS & METHODS: NB-201 was tested in in vitro and in vivo murine and porcine models infected with MRSA. RESULTS: Topical treatment of MRSA-infected wounds with NB-201 significantly decreased bacterial load and had no toxic effects on healthy skin tissues. NB-201 attenuated neutrophil sequestration in MRSA-infected wounds and inhibited epidermal and deep dermal inflammation. The levels of proinflammatory cytokines were reduced in NB-201-treated MRSA-infected wounds. CONCLUSION: NB-201 can greatly reduce inflammation characteristic of infected wounds and has antimicrobial activity that effectively kills MRSA regardless of the genetic basis of antibiotic resistance.
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