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  • Title: The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells.
    Author: Comanducci M, Ricci S, Ratti G.
    Journal: Mol Microbiol; 1988 Jul; 2(4):531-8. PubMed ID: 2845228.
    Abstract:
    Sequence analysis of a 7.5 kb DNA plasmid isolated from Chlamydia trachomatis shows 8 open reading frames (ORFs) regularly spaced along most of the sequence. One of these ORFs encodes a 451-amino-acid polypeptide highly homologous to the DnaB protein of Escherichia coli. A region between ORFs 6 and 7 contains a cluster of alternating ATs and a 22 bp sequence tandemly repeated 4 times, suggesting a replication control region. Several ORFs correspond to plasmid-specific polypeptides that have been described. Codons ending with A or T are more frequent, as might be expected from the high A/T content (64%) of the plasmid, and codon usage is similar to that of the C. trachomatis chromosomal gene, omp1L2.
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