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  • Title: Interferon gamma does not induce antiviral resistance in T lymphocytes.
    Author: Zucca M, Gribaudo G, Ferrara B, Cavallo G, Landolfo S.
    Journal: J Biol Regul Homeost Agents; 1988; 2(1):15-8. PubMed ID: 2845724.
    Abstract:
    We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses.
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