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  • Title: Transient behaviour of the Na+/K+-pump: microscopic analysis of nonstationary ion-translocation.
    Author: Läuger P, Apell HJ.
    Journal: Biochim Biophys Acta; 1988 Oct 20; 944(3):451-64. PubMed ID: 2846063.
    Abstract:
    In recent years fast perturbation techniques have been applied for investigating the mechanism of the Na+/K+-pump. Experiments in which nonstationary pump-currents and ion fluxes are measured after a voltage or ATP-concentration jump yield kinetic information which cannot be obtained from ordinary steady-state experiments. In this paper a theoretical treatment is described by which transient pump-currents and ion fluxes can be analyzed in a unified way. The method is based on the assumption that the operation of the pump involves a sequence of conformational transitions and ion-binding and -release steps. The charge displacements associated with the individual reaction steps are described by a set of dielectric coefficients. The nonstationary behaviour of the Na+/K+-pump is analyzed on the basis of the Albers-Post reaction cycle. It is shown that the different studies of transient pump-currents and ion fluxes carried out so far lead to internally consistent conclusions with respect to the nature of the electrogenic steps of the transport cycle.
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