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  • Title: Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis.
    Author: Le Pendu C, Meignin V, Gonzalez-Chiappe S, Hij A, Galateau-Sallé F, Mahr A.
    Journal: J Rheumatol; 2017 Jul; 44(7):1039-1043. PubMed ID: 28461644.
    Abstract:
    OBJECTIVE: We investigated the diagnostic value of inflammation limited to the adventitia (ILA), and isolated vasa vasorum or small-vessel vasculitis (VVV, SVV) in temporal artery biopsies (TAB) for giant cell arteritis (GCA). METHODS: Two pathologists reviewed consecutive first TAB. Using the clinical diagnoses as the gold standard, positive predictive values (PPV) were calculated. RESULTS: Among the 75 patients without classic TAB features of GCA, 8 had GCA diagnoses. The PPV of ILA, VVV, and SVV seen by either or both pathologists were 17%, 0%, and 7%, and 17%, 0%, and 10%, respectively. CONCLUSION: (Peri)adventitial infiltrates in TAB poorly predict GCA.
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