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  • Title: The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta.
    Author: Högler W, Scott J, Bishop N, Arundel P, Nightingale P, Mughal MZ, Padidela R, Shaw N, Crabtree N.
    Journal: J Clin Endocrinol Metab; 2017 Aug 01; 102(8):2734-2743. PubMed ID: 28472303.
    Abstract:
    CONTEXT: Osteogenesis imperfecta (OI) is associated with reduced muscle size, dynamic muscle function, and mobility. OBJECTIVE: To assess the effect of whole body vibration (WBV) on bone density and geometry, muscle size and function, mobility, and balance in children with OI. DESIGN: Randomized controlled pilot trial. SETTING: Tertiary pediatric research center. PARTICIPANTS: Twenty-four children (5 to 16 years) with OI types 1, 4, and limited mobility [Child Health Assessment Questionnaire (CHAQ) score ≥ 0.13] recruited in sex- and pubertal stage-matched pairs. Incident fractures in two boys (WBV arm) led to exclusion of two prepubertal pairs. INTERVENTION: Five months of WBV training (3 × 3 minutes twice daily) or regular care. MAIN OUTCOME MEASURES: Bone and muscle variables measured by dual-energy X-ray absorptiometry (spine, hip, total body) and peripheral quantitative computed tomography (tibia). Mobility assessed by 6-minute walk tests and CHAQ; dynamic muscle function by mechanography. RESULTS: All participants had reduced walking distances and muscle function (P < 0.001). Body mass index z score was associated with higher CHAQ scores (ρ + 0.552; P = 0.005) and lower walking and two-leg jumping performance (ρ - 0.405 to -0.654, P < 0.05). The WBV and control groups did not differ in the 5-month changes in bone. Total lean mass increased more in the WBV group [+1119 g (+224 to +1744)] compared with controls [+635 g (-951 to +1006)], P = 0.01, without improving mobility, muscle function, or balance. CONCLUSIONS: The increase in lean mass without changes in muscle function or bone mass suggests reduced biomechanical responsiveness of the muscle-bone unit in children with OI.
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