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  • Title: Natural history of fetal isolated ventriculomegaly: Comparison between pre- and post-natal imaging.
    Author: Perlman S, Bar-Yosef O, Jacobson JM, Gilboa Y, Derazne E, Achiron R, Katorza E.
    Journal: J Matern Fetal Neonatal Med; 2018 Jul; 31(13):1762-1767. PubMed ID: 28475388.
    Abstract:
    PURPOSE: The aim of our study was to assess the agreement between pre- and post-natal measurements in prenatal isolated ventriculomegaly. METHODS: Ninety-two women were referred for lateral ventricular abnormality and followed prospectively. Cases with at least one dilated lateral ventricle ≥10 mm and a normal work up (serological tests, detailed anatomical scan, fetal brain MR imaging, genetic counseling, and amniocentesis) were considered idiopathic ventriculomegaly and comprised the study group for post-natal follow up. Prenatal measurements were performed by ultrasound and MR imaging. Post-natal measurements were performed by cranial sonography at age of 1-3 months. Measurements were performed in the customary plane for each modality. Paired Student's t test was used to assess the mean difference between pre- and postnatal measurements. RESULTS: Forty three cases comprised the study group for post-natal measurements. A statistically significant decrease in ventricular width (p < .001) was observed between pre- and post-natal measurements. On clinical follow up for 24 months, all cases were normal except three who demonstrated very mild neurological deficits. CONCLUSIONS: Our study indicates statistically significant regression of prenatal isolated ventriculomegaly in the post-natal period.
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