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  • Title: Glutathione and thioredoxin systems of the malaria parasite Plasmodium falciparum: Partners in crime?
    Author: Chaudhari R, Sharma S, Patankar S.
    Journal: Biochem Biophys Res Commun; 2017 Jun 17; 488(1):95-100. PubMed ID: 28479253.
    Abstract:
    In P. falciparum, antioxidant proteins of the glutathione and thioredoxin systems are compartmentalized. Some subcellular compartments have only a partial complement of these proteins. This lack of key anti-oxidant proteins in certain sub-cellular compartments might be compensated by functional complementation between these systems. By assessing the cross-talk between these systems, we show for the first time, that the glutathione system can reduce thioredoxins that are poor substrates for thioredoxin reductase (Thioredoxin-like protein 1 and Thioredoxin 2) and thioredoxins that lack access to thioredoxin reductase (Thioredoxin 2). Our data suggests that crosstalk between the glutathione and thioredoxin systems does exist; this could compensate for the absence of certain antioxidant proteins from key subcellular compartments.
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