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  • Title: Angiotensin-Converting Enzyme Gene Polymorphism in Children with Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings.
    Author: Monajemzadeh M, Hesami M, Shahsiah R, Vasei M, Hooshmand S, Tanzifi P, Hajizadeh N, Ataei N, Mehrkash M, Javadi Larijani F, Moghtaderi M, Bazargani B, Khorvash R, Soleimanifar N.
    Journal: Fetal Pediatr Pathol; 2017 Aug; 36(4):265-275. PubMed ID: 28481137.
    Abstract:
    OBJECTIVE: Angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations. The aim of this study is to evaluate the distribution of the ACE I/D genotype in children with idiopathic nephrotic syndrome (INS) and healthy controls and study the effect of this polymorphism on clinical and pathologic findings. METHODS: ACE gene I/D polymorphism of 104 patients with INS and 119 controls were determined. RESULTS: The DD, ID, and II genotypes were found in 58.7%, 22.1%, and 19.2% of the patients, and in 79.8%, 2.5%, and 17.6% of controls, respectively (p > 0.05). The ID genotype was seen more frequently in patients resistant to treatment. CONCLUSION: The observed differences with previous reports suggest the influence of the genetic background on disease course. The ACE I/D gene polymorphism's role seems to be more important in renal disease progression than susceptibility.
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