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  • Title: Effects of 4-aminopyridine in experimental CNS demyelination.
    Author: Kaji R, Sumner AJ.
    Journal: Neurology; 1988 Dec; 38(12):1884-7. PubMed ID: 2848207.
    Abstract:
    We studied the effect of systemically administered 4-aminopyridine in a model of CNS demyelination. In five rats with demyelination, slowed conduction velocity through the lesion was partially reversed at dose levels of 5.6 to 7.2 mg/kg. All rats developed convulsion at this dosage, and impaired conduction of high-frequency impulses was unchanged. These findings suggest certain limitations of 4-aminopyridine as a therapeutic agent.
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